Oncogenic Competence in Melanoma: Assessing the Cancerous Potential of Different Cell Lineages to Identify New Anti-Tumor Targets
Cover Image: Melanoma in a skin biopsy with H&E stain.. (Source: Wikimedia Commons, KGH) Melanomas, like most cancers, result from genetic mutations that effect cell cycle proteins, causing uncontrollable cell replication. These mutations can occur as a cell is replicating and differentiating from pluripotent cell lineages into more specialized forms. In melanomas, the onset of a …